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Vitamin D is essential for life in higher animals.

Classically vitamin D3 has been shown to be one of the most important biological regulators of calcium metabolism through stimulating the absorption of calcium from food across the intestine and participating in the incorporation of the absorbed calcium in to the skeleton.

It has become increasingly apparent since the 1980s that 1a,25(OH)2D3 also plays an important multidisciplinary role in tissues not primarily related to mineral metabolism, e.g. the hematopoietic or blood system, effects on cell differentiation and proliferation including important interactions with keratinocytes and cancer cells, and participation in the processes of parathyroid hormone and insulin secretion.